In-vitro mutagenesis of qnrA and qnrS genes and quinolone resistance in Escherichia coli
نویسندگان
چکیده
منابع مشابه
First detection of plasmid-mediated quinolone resistance (qnrA and qnrS) in Escherichia coli strains isolated from humans in Scandinavia.
strain with no parC mutations. This is consistent with previous findings that gyrA mutations are necessary for quinolone resistance, whereas parC mutations appear to be complementary, as resistant strains do not carry parC mutations alone. – 6 Some studies further suggest that additional parC mutations facilitate increasing levels of resistance, but our study did not support this. For example, ...
متن کاملMutational analysis of quinolone resistance in the plasmid-encoded pentapeptide repeat proteins QnrA, QnrB and QnrS.
OBJECTIVES Pentapeptide repeat proteins (PRPs) QnrA, QnrB and QnrS confer reduced susceptibility to quinolones. This study presents an in vitro analysis of the genetic evolution of quinolone resistance mediated by changes in the coding sequences and promoter regions of qnrA1, qnrS1 and qnrB1 genes. METHODS A random mutagenesis technique was used to predict the evolutionary potential of these ...
متن کاملبررسی فنوتیپی و ژنوتیپی مقاومت به آنتی‌بیوتیک‌های کینولون در ایزوله‌های بالینی اشریشیاکلی جدا شده از عفونت ادراری افراد بستری در بیمارستان های شهر تهران در سال 1396
Background & Aim: Antibiotic resistance to quinolones as a therapeutic agent of urinary tract infection in increasing in the world. Thus, this study was designed to evaluate the resistance to quinolone antibiotics in Escherichia coli isolated from urinary tract infection of hospitalized patients in Tehran, Iran in 2017. Methods: In the present study, 150 E. coli isolates was collected from uri...
متن کاملQuinolone resistance in Escherichia coli.
Escherichia coli is an important pathogen of animals and humans that causes great financial cost in food production by causing disease in food animals. The quinolones are a class of synthetic antimicrobial agents with excellent activity against Escherichia coli and other Gram-negative bacteria used in human and veterinary medicine. Different quinolones are used to treat various conditions in an...
متن کاملفراوانی ژن‌های پلاسمیدی qnrA، qnrB و qnrS و تعیین حساسیت آنتی بیوتیکی در ایزوله‌های اشرشیاکلی مقاوم به کینولون و فلوروکینولون جدا شده از نمونه‌های بالینی کرمان
Background: Plasmid-mediated quinolone resistance, which complicates treatment, has been increasingly identified in Escherichia coli isolates worldwide. The purpose of this study was to investigate the frequency of plasmid-mediated qnrA, qnrB, and qnrS genes among quinolones resistant E.coli isolated from Kerman hospitals, Iran. Methods: In the current study, 80 E. coli isolates...
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ژورنال
عنوان ژورنال: Clinical Microbiology and Infection
سال: 2007
ISSN: 1198-743X
DOI: 10.1111/j.1469-0691.2007.01778.x